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IL-10 gene promoter and intron polymorphisms and changes in IL-10 secretion in women with idiopathic recurrent miscarriage.

Human reproduction (Oxford, England) - 1 May 2014

Qaddourah R H, Magdoud K, Saldanha F L, Mahmood N, Mustafa F E, Mahjoub T, Almawi W Y

Abstract excerpt

STUDY QUESTION: Is recurrent pregnancy loss (RPL) associated with polymorphisms in the promoter and intron regions of the interleukin-10 (IL-10) gene? SUMMARY ANSWER: IL-10 rs1518111 was found to be associated with RPL but the commonly studied promoter variants rs1800872, rs1800871 and 1800896 were not. WHAT IS KNOWN ALREADY: Reduced expression of IL-10 is implicated in RPL, due to defective maternal immune...

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PMID: 24626804
DOI: 10.1093/humrep/deu043

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