Article
Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence.
Addiction (Abingdon, England) - 1 Mar 2009
Agrawal Arpana, Pergadia Michele L, Balasubramanian Sumitra, Saccone Scott F, Hinrichs Anthony L, Saccone Nancy L, Breslau Naomi, Johnson Eric O, Hatsukami Dorothy, Martin Nicholas G, Montgomery Grant W, Goate Alison M, Rice John P, Bierut Laura J, Madden Pamela A F
Abstract excerpt
AIMS: A previous association analysis identified polymorphisms in gamma-aminobutyric acid receptor A, subunit 4 (GABRA4) and GABRA2 to be associated with nicotine dependence, as assessed by a score of 4 or more on the Fagerström Test for Nicotine Dependence (FTND). In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes. DESIGN: In 1049 cases (FTND...
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