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Article

Effect of CYP3A5*3 genotype on exposure and efficacy of quetiapine: A retrospective, cohort study.

Journal of affective disorders - 1 Feb 2025

Zhao Yan, Hao Yupei, Wang Ziyi, Liu Shuai, Yuan Shizhao, Zhou Chunhua, Yu Jing

Abstract excerpt

BACKGROUND: The involvement of cytochrome P450 3A5 (CYP3A5) in the metabolism of quetiapine has been proposed, though conclusive evidence is lacking. This study aimed to quantitatively assess the impact of CYP3A5 genetic variability on quetiapine exposure in a Chinese patient population. METHODS: Patient data were retrospectively collected from the database of the Mental Health Centre at the First Hospital of...

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PMID: 39490424
DOI: 10.1016/j.jad.2024.10.112

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