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Article

Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death.

American journal of respiratory and critical care medicine - 1 May 2009

Ahmad Shama, Ahmad Aftab, Dremina Elena S, Sharov Victor S, Guo Xiaoling, Jones Tara N, Loader Joan E, Tatreau Jason R, Perraud Anne-Laure, Schöneich Christian, Randell Scott H, White Carl W

Abstract excerpt

RATIONALE: Modulation of the activity of sarcoendoplasmic reticulum calcium ATPase (SERCA) can profoundly affect Ca(2+) homeostasis. Although altered calcium homeostasis is a characteristic of cystic fibrosis (CF), the role of SERCA is unknown. OBJECTIVES: This study provides a comprehensive investigation of expression and activity of SERCA in CF airway epithelium. A detailed study of the mechanisms underlying...

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Source

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Identifiers

PMID: 19201925
DOI: 10.1164/rccm.200807-1104OC
PMCID: PMC2675566

Genes

CFTR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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