Article
Genotype regulates the development of tolerance to ethanol and cross-tolerance to nicotine.
Alcohol (Fayetteville, N.Y.) - 1 Jan 2000
Luo Y, Marks M J, Collins A C
Abstract excerpt
The long-sleep (LS) and short-sleep (SS) mouse lines were selectively bred for differential sensitivity to the anesthetic actions of ethanol, but they also differ in sensitivity to nicotine. A recent study suggested that the LS mice develop more tolerance to ethanol and cross-tolerance to nicotine than do the SS following chronic ethanol treatment. The studies reported here expand on these previous studies by...
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