Article
High CD8+ T cell activation marks a less differentiated HIV-1 specific CD8+ T cell response that is not altered by suppression of viral replication.
PloS one - 1 Jan 2009
Barbour Jason D, Ndhlovu Lishomwa C, Xuan Tan Qi, Ho Terence, Epling Lorrie, Bredt Barry M, Levy Jay A, Hecht Frederick M, Sinclair Elizabeth
Abstract excerpt
BACKGROUND: The relationship of elevated T cell activation to altered T cell differentiation profiles, each defining features of HIV-1 infection, has not been extensively explored. We hypothesized that anti-retroviral suppression of T cell activation levels would lead to alterations in the T cell differentiation of total and HIV-1 specific CD8+ T cell responses among recently HIV-1 infected adults....
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