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Article

Immune Activation and CD8+ T-Cell Differentiation towards Senescence in HIV-1 Infection

13 Feb 2004

Abstract excerpt

Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor outcome in HIV-1 pathogenesis. However, the basis of this association remains unclear. Through ex vivo analysis of virus-specific CD8(+) T-cells and the use of an in...

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PMID: 14966528
DOI: 10.1371/journal.pbio.0020020

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