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Article

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

PLoS genetics - 1 Feb 2009

Lowe Jennifer K, Maller Julian B, Pe'er Itsik, Neale Benjamin M, Salit Jacqueline, Kenny Eimear E, Shea Jessica L, Burkhardt Ralph, Smith J Gustav, Ji Weizhen, Noel Martha, Foo Jia Nee, Blundell Maude L, Skilling Vita, Garcia Laura, Sullivan Marcia L, Lee Heather E, Labek Anna, Ferdowsian Hope, Auerbach Steven B, Lifton Richard P, Newton-Cheh Christopher, Breslow Jan L, Stoffel Markus, Daly Mark J, Altshuler David M, Friedman Jeffrey M

Abstract excerpt

It has been argued that the limited genetic diversity and reduced allelic heterogeneity observed in isolated founder populations facilitates discovery of loci contributing to both Mendelian and complex disease. A strong founder effect, severe isolation, and substantial inbreeding have dramaticall...

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Identifiers

PMID: 19197348
DOI: 10.1371/journal.pgen.1000365
PMCID: PMC2628735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19197348-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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