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Article

Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia.

Nature genetics - 1 Feb 2006

Bonnen Penelope E, Pe'er Itsik, Plenge Robert M, Salit Jackie, Lowe Jennifer K, Shapero Michael H, Lifton Richard P, Breslow Jan L, Daly Mark J, Reich David E, Jones Keith W, Stoffel Markus, Altshuler David, Friedman Jeffrey M

Abstract excerpt

Whole-genome association studies are predicted to be especially powerful in isolated populations owing to increased linkage disequilibrium (LD) and decreased allelic diversity, but this possibility has not been empirically tested. We compared genome-wide data on 113,240 SNPs typed on 30 trios from the Pacific island of Kosrae to the same markers typed in the 270 samples from the International HapMap Project. The...

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PMID: 16429162
DOI: 10.1038/ng1712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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