Article
Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 2009
Kenny Eimear E, Gusev Alexander, Riegel Kaitlin, Lütjohann Dieter, Lowe Jennifer K, Salit Jacqueline, Maller Julian B, Stoffel Markus, Daly Mark J, Altshuler David M, Friedman Jeffrey M, Breslow Jan L, Pe'er Itsik, Sehayek Ephraim
Abstract excerpt
Pinpointing culprit causal variants along signal peaks of genome-wide association studies (GWAS) is challenging. To overcome confounding effects of multiple independent variants at such a locus and narrow the interval for causal allele capture, we developed an approach that maps local shared haplotypes harboring a putative causal variant. We demonstrate our method in an extreme isolate founder population, the...
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