Article
Leptin receptor polymorphisms and lung function decline in COPD.
The European respiratory journal - 1 Jul 2009
Hansel N N, Gao L, Rafaels N M, Mathias R A, Neptune E R, Tankersley C, Grant A V, Connett J, Beaty T H, Wise R A, Barnes K C
Abstract excerpt
Only a fraction of all smokers develop chronic obstructive pulmonary disease (COPD), suggesting a large role for genetic susceptibility. The leptin receptor (LEPR) is present in human lung tissue and may play a role in COPD pathogenesis. The present study examined the association between genetic variants in the LEPR gene and lung function decline in COPD. In total, 429 European Americans were randomly selected...
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