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Article

Decorin and TGF-beta1 polymorphisms and development of COPD in a general population.

Respiratory research - 16 Jun 2006

van Diemen Cleo C, Postma Dirkje S, Vonk Judith M, Bruinenberg Marcel, Nolte Ilja M, Boezen H Marike

Abstract excerpt

BACKGROUND: Decorin, an extracellular matrix (ECM) proteoglycan, and TGF-beta1 are both involved in lung ECM turnover. Decorin and TGF-beta1 expression are decreased respectively increased in COPD lung tissue. Interestingly, they act as each other's feedback regulator. We investigated whether single nucleotide polymorphisms (SNPs) in decorin and TGF-beta1 underlie accelerated decline in FEV1 and development of...

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Identifiers

PMID: 16780585
DOI: 10.1186/1465-9921-7-89
PMCID: PMC1539000

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