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Article

Submicroscopic gametocytes and the transmission of antifolate-resistant Plasmodium falciparum in Western Kenya.

PloS one - 1 Jan 2009

Oesterholt Mayke J A M, Alifrangis Michael, Sutherland Colin J, Omar Sabah A, Sawa Patrick, Howitt Christina, Gouagna Louis C, Sauerwein Robert W, Bousema Teun

Abstract excerpt

BACKGROUND: Single nucleotide polymorphisms (SNPs) in the dhfr and dhps genes are associated with sulphadoxine-pyrimethamine (SP) treatment failure and gametocyte carriage. This may result in enhanced transmission of mutant malaria parasites, as previously shown for chloroquine resistant parasites. In the present study, we determine the association between parasite mutations, submicroscopic P. falciparum...

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Identifiers

PMID: 19194499
DOI: 10.1371/journal.pone.0004364
PMCID: PMC2632751

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Source receipt: pubmed, retrieved 7 Sept 2026.

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