Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya.

doi:10.1186/s12879-025-10462-z

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Article

Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya.

BMC infectious diseases - 16 Jan 2025

Osoti Victor, Wamae Kevin, Ndwiga Leonard, Gichuki Paul M, Okoyo Collins, Kepha Stella, Keitany Kibor, Kandie Regina, Aricha Stephen, Kiplagat Rosebella, Mwandawiro Charles, Bejon Philip, Snow Robert W, Ochola-Oyier Lynette Isabella

Abstract excerpt

BACKGROUND: To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. Recent advances in next-generation sequencing (NGS) technologies have enabled the tracking of drug-resistant malaria parasites. METHODS: In this study, we used Targeted Amplicon Deep Sequencing (TADS) to characterise the...

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Topics

Humans
Kenya
Drug Resistance
Artemisinins
Antimalarials

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Child

Plasmodium falciparum

Mutation

Malaria, Falciparum

Male

Female

Protozoan Proteins

High-Throughput Nucleotide Sequencing

Schools

Source

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Identifiers

PMID: 39819451
DOI: 10.1186/s12879-025-10462-z
PMCID: PMC11740484

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