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Article

Directional selection at the pfmdr1, pfcrt, pfubp1, and pfap2mu loci of Plasmodium falciparum in Kenyan children treated with ACT.

The Journal of infectious diseases - 15 Dec 2014

Henriques Gisela, Hallett Rachel L, Beshir Khalid B, Gadalla Nahla B, Johnson Rachel E, Burrow Rebekah, van Schalkwyk Donelly A, Sawa Patrick, Omar Sabah A, Clark Taane G, Bousema Teun, Sutherland Colin J

Abstract excerpt

BACKGROUND: The efficacy of artemisinin-based combination therapy (ACT) for Plasmodium falciparum malaria may be threatened by parasites with reduced responsiveness to artemisinins. Among 298 ACT-treated children from Mbita, Kenya, submicroscopic persistence of P. falciparum on day 3 posttreatment was associated with subsequent microscopically detected parasitemia at days 28 or 42. METHODS: DNA sequences of...

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PMID: 24994911
DOI: 10.1093/infdis/jiu358
PMCID: PMC4241946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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