Article
CYP 450 2C19 polymorphisms in Indian patients with coronary artery disease.
Indian heart journal - 1 Jan 2000
Shetkar Sudhir S, Ramakrishnan Sivasubramanian, Seth Sandeep, Chandna Puneet, Verma Sunil K, Bhargava Balram, Bahl Vinay K
Abstract excerpt
BACKGROUND: Dual antiplatelet therapy is the cornerstone in the management of acute coronary syndromes (ACS) and prevention of stent thrombosis (ST). Genetic polymorphisms in CYP2C19 gene involved in hepatic activation of clopidogrel leads to clopidogrel non-responsiveness and may influence clinical outcomes. These polymorphisms in CYP2C19 gene and their impact on clinical outcome in coronary artery disease (CAD)...
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