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Article

A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs.

Biology direct - 3 Jun 2014

Dingerdissen Hayley, Weaver Daniel S, Karp Peter D, Pan Yang, Simonyan Vahan, Mazumder Raja

Abstract excerpt

BACKGROUND: We have previously suggested a method for proteome wide analysis of variation at functional residues wherein we identified the set of all human genes with nonsynonymous single nucleotide variation (nsSNV) in the active site residue of the corresponding proteins. 34 of these proteins were shown to have a 1:1:1 enzyme:pathway:reaction relationship, making these proteins ideal candidates for laboratory...

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Identifiers

PMID: 24894379
DOI: 10.1186/1745-6150-9-9
PMCID: PMC4057618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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