Article
Association studies and gene expression analyses of the DISC1-interacting molecules, pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ), with schizophrenia and with bipolar disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2009
Anitha Ayyappan, Nakamura Kazuhiko, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Takei Nori, Iwata Yasuhide, Suzuki Katsuaki, Sekine Yoshimoto, Matsuzaki Hideo, Kawai Masayoshi, Thanseem Ismail, Miyoshi Ko, Katayama Taiichi, Matsuzaki Shinsuke, Baba Kousuke, Honda Akiko, Hattori Tsuyoshi, Shimizu Shoko, Kumamoto Natsuko, Kikuchi Mitsuru, Tohyama Masaya, Yoshikawa Takeo, Mori Norio
Abstract excerpt
Disrupted-in-Schizophrenia 1 (DISC1) and its molecular cascade have been implicated in the pathophysiology of major psychoses. Previously, we identified pericentrin 2 (PCNT2) and DISC1-binding zinc finger protein (DBZ) as binding partners of DISC1; further, we observed elevated expression of PCNT2 in the postmortem brains and in the lymphocytes of bipolar disorder patients, compared to controls. Here, we examined...
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