Article
Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder.
Biological psychiatry - 1 Apr 2008
Anitha Ayyappan, Nakamura Kazuhiko, Yamada Kazuo, Iwayama Yoshimi, Toyota Tomoko, Takei Nori, Iwata Yasuhide, Suzuki Katsuaki, Sekine Yoshimoto, Matsuzaki Hideo, Kawai Masayoshi, Miyoshi Ko, Katayama Taiichi, Matsuzaki Shinsuke, Baba Kousuke, Honda Akiko, Hattori Tsuyoshi, Shimizu Shoko, Kumamoto Natsuko, Tohyama Masaya, Yoshikawa Takeo, Mori Norio
Abstract excerpt
BACKGROUND: DISC1 has been suggested as a causative gene for psychoses in a large Scottish kindred. PCNT2 has recently been identified as an interacting partner of DISC1. In this study, we investigated the role of PCNT2 in bipolar disorder, by gene expression analysis and genetic association study. METHODS: By TaqMan real-time quantitative reverse transcriptase polymerase chain reaction (qRT-PCR), we examined the...
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