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Article

Somatic mutation and functional polymorphism of a novel regulatory element in the HGF gene promoter causes its aberrant expression in human breast cancer.

The Journal of clinical investigation - 1 Mar 2009

Ma Jihong, DeFrances Marie C, Zou Chunbin, Johnson Carla, Ferrell Robert, Zarnegar Reza

Abstract excerpt

The HGF gene is transcriptionally silenced in normal differentiated breast epithelial cells, but its repression fails to occur in mammary carcinoma tissues and cell lines. The molecular mechanisms underpinning aberrant HGF expression in breast cancer cells are unknown. Here we report the discovery of a DNA element located 750 bp upstream from the transcription start site in the human HGF promoter that acts as a...

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Source

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Identifiers

PMID: 19188684
DOI: 10.1172/JCI36640
PMCID: PMC2648687

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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