Article
Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis.
Gastroenterology - 1 Jan 2015
Seneviratne Danushka, Ma Jihong, Tan Xinping, Kwon Yong-Kook, Muhammad Eman, Melhem Mona, DeFrances Marie C, Zarnegar Reza
Abstract excerpt
BACKGROUND & AIMS: Genomic instability promotes colon carcinogenesis by inducing genetic mutations, but not all genes affected by this process have been identified. We investigated whether genomic instability in human colorectal cancer (CRC) cells produces mutations in the hepatocyte growth factor (HGF) gene. METHODS: We genotyped human colon tumor tissues and adjacent nontumor tissues collected from 78 patients...
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