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Article

mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.

Nature medicine - 1 Jun 2004

Majumder Pradip K, Febbo Phillip G, Bikoff Rachel, Berger Raanan, Xue Qi, McMahon Louis M, Manola Judith, Brugarolas James, McDonnell Timothy J, Golub Todd R, Loda Massimo, Lane Heidi A, Sellers William R

Abstract excerpt

Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition is useful in treating PTEN-null cancers. Here, we report that mTOR inhibition induced apoptosis of epithelial cells and the complete reversal of a neoplastic phenotype in the prostate of mice expressing human AKT1 in the ventral...

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Source

Identifiers

PMID: 15156201
DOI: 10.1038/nm1052

Genes

BCL2
PTEN
AKT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways.PMID 15156201Read ↗

Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.Semantic proximity Read ↗

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A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.Semantic proximity Read ↗

IR-B deficiency and fatty acid dysregulation accelerate prostate cancer progression via PI3K/AKT signalingSemantic proximity Read ↗

A constitutively activated form of the p110β isoform of PI3-kinase induces prostatic intraepithelial neoplasia in miceSemantic proximity Read ↗

<i>Pten</i> Deficiency Activates Distinct Downstream Signaling Pathways in a Tissue-Specific MannerSemantic proximity Read ↗

mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice.Semantic proximity Read ↗

MYC cooperates with AKT in prostate tumorigenesis and alters sensitivity to mTOR inhibitors.Semantic proximity Read ↗

Down-modulation of Bcl-2 sensitizes PTEN-mutated prostate cancer cells to starvation and taxanes.Semantic proximity Read ↗

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