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Article

Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.

Molecular microbiology - 1 Mar 2009

Murta Silvane M F, Vickers Tim J, Scott David A, Beverley Stephen M

Abstract excerpt

10-Formyl tetrahydrofolate (10-CHO-THF) is a key metabolite in C1 carbon metabolism, arising through the action of formate-tetrahydrofolate ligase (FTL) and/or 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase (DHCH). Leishmania major possesses single DHCH1 and FTL genes encoding exclusively cytosolic proteins, unlike other organisms where isoforms occur in the...

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Identifiers

PMID: 19183277
DOI: 10.1111/j.1365-2958.2009.06610.x
PMCID: PMC2692627

Genes

FTL

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Source receipt: pubmed, retrieved 7 Sept 2026.

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