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Article

Genetic and epigenetic mechanisms combine to control MMP1 expression and its association with preterm premature rupture of membranes.

Human molecular genetics - 15 Apr 2008

Wang Hongyan, Ogawa Masaki, Wood Jennifer R, Bartolomei Marisa S, Sammel Mary D, Kusanovic Juan Pedro, Walsh Scott W, Romero Roberto, Strauss Jerome F

Abstract excerpt

Degradation of fibrillar collagens is believed to be involved in the rupture of the fetal membranes during normal parturition and when the membranes rupture prematurely. Matrix metalloproteinase 1 (MMP1) is a key enzyme involved in extracellular matrix turnover, and genetic variation in the MMP1 promoter is associated with the risk of preterm premature rupture of membranes (PPROM). We determined whether...

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Source

Identifiers

PMID: 18178580
DOI: 10.1093/hmg/ddm381

Genes

MMP1

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