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Conditional Deletion of Beta-Catenin Mediated by Amhr2cre in Mice Causes Female Infertility1

29 Jan 2009

Abstract excerpt

Follicle-stimulating hormone (FSH) regulation of aromatase gene expression in vitro requires the transcriptional coactivator beta-catenin. To ascertain the physiological significance of beta-catenin in granulosa cells during folliculogenesis, mice homozygous for floxed alleles of beta-catenin were intercrossed with Amhr2cre mice. Conditional deletion of beta-catenin in 8-wk-old females occurred in derivatives of...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 19176883
DOI: 10.1095/biolreprod.108.072280

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