Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimullerian hormone expression during oocyte maturation in the female follicle

Abstract excerpt

Wnt4 is a key signal that channels the developmental fate of the indifferent mammalian gonad toward the ovary, but whether Wnt4 has later roles during ovary development remains unknown. To investigate this, we inactivated the Wnt4 gene by crossing Amhr2Cre and doxycycline‐inducible Rosa rtTA ‐knock‐in Cre mice with mice carrying a floxed Wnt4 allele and used a novel Wnt4 mCherry ‐knock‐in mouse. In these models,...

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