Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula.

Development (Cambridge, England) - 1 Mar 2009

van Impel Andreas, Schumacher Sabine, Draga Margarethe, Herz Hans-Martin, Grosshans Jörg, Müller H Arno J

Abstract excerpt

The Drosophila guanine nucleotide exchange factor Pebble (Pbl) is essential for cytokinesis and cell migration during gastrulation. In dividing cells, Pbl promotes Rho1 activation at the cell cortex, leading to formation of the contractile actin-myosin ring. The role of Pbl in fibroblast growth factor-triggered mesoderm spreading during gastrulation is less well understood and its targets and subcellular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrula

Share to Genes, Insect

Share to Guanine Nucleotide Exchange Factors

Share to Mesoderm

Share to rac GTP-Binding Proteins

Share to rho GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19176590
DOI: 10.1242/dev.026203
PMCID: PMC2685947

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula.PMID 19176590Read ↗

The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless.Semantic proximity Read ↗

The epithelial-mesenchymal transition of the Drosophila mesoderm requires the Rho GTP exchange factor Pebble.Semantic proximity Read ↗

Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis.Semantic proximity Read ↗

Genghis Khan (Gek) as a putative effector for <i>Drosophila</i> Cdc42 and regulator of actin polymerizationSemantic proximity Read ↗

Drosophila PDZ-GEF, a guanine nucleotide exchange factor for Rap1 GTPase, reveals a novel upstream regulatory mechanism in the mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

DRhoGEF2 regulates actin organization and contractility in the Drosophila blastoderm embryo.Semantic proximity Read ↗

Reduced cell number in the hindgut epithelium disrupts hindgut left-right asymmetry in a mutant of pebble, encoding a RhoGEF, in Drosophila embryos.Semantic proximity Read ↗

A rho-binding protein kinase C-like activity is required for the function of protein kinase N in Drosophila development.Semantic proximity Read ↗

In Drosophila melanogaster, the rolling pebbles isoform 6 (Rols6) is essential for proper Malpighian tubule morphology.Semantic proximity Read ↗

Fine-Tuning of the Actin Cytoskeleton and Cell Adhesion During Drosophila Development by the Unconventional Guanine Nucleotide Exchange Factors Myoblast City and Sponge.Semantic proximity Read ↗

Diaphanous-Related Formin 2 and Profilin I Are Required for Gastrulation Cell MovementsSemantic proximity Read ↗

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.