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Article

Igf1r as a therapeutic target in a mouse model of basal-like breast cancer

27 Jan 2009

Abstract excerpt

Considering the strong association between dysregulated insulin-like growth factor (IGF) signaling and various human cancers, we have used an expedient combination of genetic analysis and pharmacological treatment to evaluate the potential of the type 1 IGF receptor (Igf1r) for targeted anticancer therapy in a mouse model of mammary tumorigenesis. In this particular strain of genetically modified animals,...

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Share to Glycosylation and Glycoproteins Research
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PMID: 19174523
DOI: 10.1073/pnas.0810221106

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