Article
Reprograming of peripheral Foxp3+ regulatory T cell towards Th17-like cell in patients with active systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.) - 1 Dec 2019
Jiang Cen, Wang Huaizhou, Xue Minghui, Lin Lin, Wang Jianbiao, Cai Gang, Shen Qian
Abstract excerpt
Treg is essential to limit the extend and duration of the immune response, but its stability is still under debate. Here we demonstrate that IL-17-producing Treg cells (Th17-like cells) increased in peripheral blood of patients with Systemic Lupus Erythematosus (SLE). Notably, the Th17-like cells from patient with active SLE were characterized with some phenotype and function of Th17 cells. Upon stimulation,...
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