Article
Two separate effects contribute to regulatory T cell defect in systemic lupus erythematosus patients and their unaffected relatives.
Clinical and experimental immunology - 1 Sept 2017
Costa N, Marques O, Godinho S I, Carvalho C, Leal B, Figueiredo A M, Vasconcelos C, Marinho A, Moraes-Fontes M F, Gomes da Costa A, Ponte C, Campanilho-Marques R, Cóias T, Martins A R, Viana J F, Lima M, Martins B, Fesel C
Abstract excerpt
Forkhead box P3 (FoxP3)+ regulatory T cells (Tregs ) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)-2 receptor alpha chain]. Low-dose IL-2 therapy is a promising current approach to correct this defect. To elucidate the origins of the SLE Treg phenotype, we studied its role through developmentally defined regulatory T cell (Treg )...
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