Article
Evaluating the impact of scoring parameters on the structure of intra-specific genetic variation using RawGeno, an R package for automating AFLP scoring.
BMC bioinformatics - 26 Jan 2009
Arrigo Nils, Tuszynski Jarek W, Ehrich Dorothee, Gerdes Tommy, Alvarez Nadir
Abstract excerpt
BACKGROUND: Since the transfer and application of modern sequencing technologies to the analysis of amplified fragment-length polymorphisms (AFLP), evolutionary biologists have included an increasing number of samples and markers in their studies. Although justified in this context, the use of automated scoring procedures may result in technical biases that weaken the power and reliability of further analyses....
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