Article
Haplotyping RAD loci: an efficient method to filter paralogs and account for physical linkage.
Molecular ecology resources - 1 Sept 2017
Willis Stuart C, Hollenbeck Christopher M, Puritz Jonathan B, Gold John R, Portnoy David S
Abstract excerpt
Next-generation sequencing of reduced-representation genomic libraries provides a powerful methodology for genotyping thousands of single-nucleotide polymorphisms (SNPs) among individuals of nonmodel species. Utilizing genotype data in the absence of a reference genome, however, presents a number of challenges. One major challenge is the trade-off between splitting alleles at a single locus into separate clusters...
Topics
- Computational Biology
- Genetic Loci
- Genomics
- Genotyping Techniques
- Haplotypes
- High-Throughput Nucleotide Sequencing
- Polymorphism, Single Nucleotide