Article
Raw mediates antagonism of AP-1 activity in Drosophila.
Genetics - 1 Apr 2008
Bates Katherine L, Higley Matthew, Letsou Anthea
Abstract excerpt
High baselines of transcription factor activities represent fundamental obstacles to regulated signaling. Here we show that in Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) signaling cascade. Our studies indicate that the novel raw gene product is required to limit AP-1...
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