Association between manganese superoxide dismutase polymorphism and risk of lung cancer.

Abstract excerpt

Manganese superoxide dismutase (MnSOD) is one of the major enzymes responsible for the defense against oxidative damage due to reactive oxygen species (ROS) in the mitochondria. C-->T substitution in the MnSOD gene (SOD2) produces an Ala-->Val change at amino acid 16, in the mitochondrial targeting sequence of the MnSOD precursor. This seems to reduce transport of the enzyme into mitochondria, decreasing its...

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