Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.

doi:10.17305/bjbms.2020.5368

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Article

Sirtuin 1 rs7069102 polymorphism is associated with diabetic nephropathy in patients with type 2 diabetes mellitus.

Bosnian journal of basic medical sciences - 1 Oct 2021

Letonja Jernej, Završnik Matej, Makuc Jana, Šeruga Maja, Peterlin Ana, Cilenšek Ines, Petrovič Danijel

Abstract excerpt

The global prevalence for diabetes mellitus nearly doubled from 4.7% in 1980 to 8.5% in 2014. Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase that is expressed in a variety of tissues. It modifies proteins that participate in DNA repair, stress, and inflammatory response. The aim of the study was to investigate the relationship between SIRT1 rs7069102 polymorphism and diabetic nephropathy (DN) in patients with...

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PMID: 33577446
DOI: 10.17305/bjbms.2020.5368
PMCID: PMC8381203

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