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Article

Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.

Circulation - 4 Sept 2001

Viswanathan P C, Bezzina C R, George A L, Roden D M, Wilde A A, Balser J R

Abstract excerpt

BACKGROUND: Mutations in the cardiac sodium (Na) channel gene (SCN5A) give rise to the congenital long-QT syndrome (LQT3) and the Brugada syndrome. Na channel blockade by antiarrhythmic drugs improves the QT interval prolongation in LQT3 but worsens the Brugada syndrome ST-segment elevation. Although Na channel blockade has been proposed as a treatment for LQT3, flecainide also evokes "Brugada-like" ST-segment...

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Source

Identifiers

PMID: 11535580
DOI: 10.1161/hc3501.093797

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gating-dependent mechanisms for flecainide action in SCN5A-linked arrhythmia syndromes.PMID 11535580Read ↗

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