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Article

Distinct conformational changes in activated agonist-bound and agonist-free glycine receptor subunits.

Journal of neurochemistry - 1 Mar 2009

Pless Stephan A, Lynch Joseph W

Abstract excerpt

Ligand binding to Cys-loop receptors produces either global conformational changes that lead to activation or local conformational changes that do not. We found that the fluorescence of a fluorophore tethered to R271C in the extracellular M2 region of the alpha1 glycine receptor increases during glycine activation but not during ivermectin activation. This prompted the hypothesis that this signal reports a...

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PMID: 19166513
DOI: 10.1111/j.1471-4159.2009.05930.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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