Article
In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection.
PloS one - 1 Jan 2009
Lubong Sabado Rachel, Kavanagh Daniel G, Kaufmann Daniel E, Fru Karlhans, Babcock Ethan, Rosenberg Eric, Walker Bruce, Lifson Jeffrey, Bhardwaj Nina, Larsson Marie
Abstract excerpt
BACKGROUND: The requirements for priming of HIV-specific T cell responses initially seen in infected individuals remain to be defined. Activation of T cell responses in lymph nodes requires cell-cell contact between T cells and DCs, which can give concurrent activation of T cells and HIV transmission. METHODOLOGY: The study aim was to establish whether DCs pulsed with HIV-1 could prime HIV-specific T cell...
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