Article
CYP3A4*1B and NAT2*14 alleles in a native African population.
Clinical chemistry and laboratory medicine - 1 Apr 2003
Cavaco Isa, Reis Rita, Gil J Pedro, Ribeiro Vera
Abstract excerpt
Single nucleotide polymorphisms were examined in the cytochrome 450 3A4 (CYP3A4) and N-acetyltransferase 2 (NAT2) genes, which code for major mediators of the metabolism of a wide variety of therapeutic drugs, as well as xenobiotics. We determined, in a population from Guinea-Bissau, the frequencies of CYP3A4 and NAT2 variants expected to be prevalent among Africans, due to the high frequency previously observed...
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