Article
MUTYH Gln324His gene polymorphism and genetic susceptibility for lung cancer in a Japanese population.
Journal of experimental & clinical cancer research : CR - 22 Jan 2009
Miyaishi Aiko, Osawa Kayo, Osawa Yasunori, Inoue Natsuko, Yoshida Kana, Kasahara Mayumi, Tsutou Akimitsu, Tabuchi Yoshiki, Sakamoto Kazuo, Tsubota Noriaki, Takahashi Juro
Abstract excerpt
BACKGROUND: Genetic polymorphisms of DNA repair enzymes in the base excision repair (BER) pathway, may lead to genetic instability and lung cancer carcinogenesis. We investigated the interactions among the gene polymorphisms in DNA repair genes and lung cancer. METHODS: We analyzed associations among OGG1 Ser326Cys and MUTYH Gln324His gene polymorphisms in relation to lung cancer risk using PCR-RFLP. The study...
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