Article
A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity.
Blood - 15 Sept 1995
Fabry M E, Sengupta A, Suzuka S M, Costantini F, Rubin E M, Hofrichter J, Christoph G, Manci E, Culberson D, Factor S M, Nagel R L
Abstract excerpt
We report on a second generation of transgenic mice produced by crossing a transgenic mouse line expressing high levels of human alpha and beta S chains (alpha H beta S [beta MDD]) with a line expressing human alpha and beta S-Antilles (beta SAnt). We hypothesized that mice expressing both hemogl...
Topics
- Anemia, Sickle Cell
- Animals
- Brain
- Centrifugation, Density Gradient
- Crosses, Genetic
- Disease Models, Animal
- Erythrocyte Count
- Erythrocytes, Abnormal
- Globins
- Hemoglobin, Sickle
- Hemoglobins
- Hemoglobins, Abnormal
- Heterozygote
- Humans
- Kidney