Article
A family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder in 378 families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2009
Shugart Y Y, Wang Y, Samuels J F, Grados M A, Greenberg B D, Knowles J A, McCracken J T, Rauch S L, Murphy D L, Rasmussen S A, Cullen B, Hoehn-Saric R, Pinto A, Fyer A J, Piacentini J, Pauls D L, Bienvenu O J, Riddle M A, Liang K Y, Nestadt G
Abstract excerpt
SLC1A encodes the neuronal and epithelial glutamate transporter and was previously tested as a candidate for obsessive-compulsive disorder (OCD) by several research groups. Recently, three independent research groups reported significant association findings between OCD and several genetic variants in SLC1A1. This study reports the results from a family-based association study, which examined the association...
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