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Article

The frequency of the ACTN3 polymorphism in Brazil: a systematic review and meta-analysis.

BMC medical genomics - 26 Apr 2025

Silvino Valmir Oliveira, Ferreira Cirley Pinheiro, Apaza Helen Matias, de Souza-Junior Valtemir Silvino, Ribeiro Sérgio Luís Galan, Almeida Sandro Soares, Dos Santos Marcos Antonio Pereira

Abstract excerpt

BACKGROUND: The ACTN3 gene encodes the protein alpha-actinin-3, which is crucial for fast-twitch muscle fibers, contributing to rapid and forceful contractions. The distribution of these genotypes and their impact on sports performance in Brazilian populations are not well-documented. This study aimed to determine the allelic and genotypic frequency of the ACTN3 R/X polymorphism in Brazil and its association with...

Read the complete abstract on PubMed

Topics

Actinin
Humans
Brazil
Gene Frequency
Athletic Performance
Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Genetic

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40287724
DOI: 10.1186/s12920-025-02136-1
PMCID: PMC12034205

Genes

ACTN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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