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Article

ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Jul 2005

Clarkson Priscilla M, Devaney Joseph M, Gordish-Dressman Heather, Thompson Paul D, Hubal Monica J, Urso Maria, Price Thomas B, Angelopoulos Theodore J, Gordon Paul M, Moyna Niall M, Pescatello Linda S, Visich Paul S, Zoeller Robert F, Seip Richard L, Hoffman Eric P

Abstract excerpt

The alpha-actinin 3 (ACTN3) gene encodes a protein of the Z disk of myofibers, and a polymorphism of ACTN3 results in complete loss of the protein. The ACTN3 genotype (R577X) has been found to be associated with performance in Australian elite athletes (Yang N, MacArthur DG, Gulbin JP, Hahn AG, B...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15718405
DOI: 10.1152/japplphysiol.01139.2004

Genes

ACTN3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-15718405-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women.PMID 15718405Read ↗

ACTN3 genotype is associated with muscle phenotypes in women across the adult age span.Semantic proximity Read ↗

Strength, power, fiber types, and mRNA expression in trained men and women with different ACTN3 R577X genotypes.Semantic proximity Read ↗

ACTN3 genotype and modulation of skeletal muscle response to exercise in human subjects.Semantic proximity Read ↗

Association of the ACTN3 Genotype with Muscle Function: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

alpha-actinin-3 and performance.Semantic proximity Read ↗

ACTN3: A genetic influence on muscle function and athletic performance.Semantic proximity Read ↗

Human alpha-actinin-3 genotype association with exercise-induced muscle damage and the repeated-bout effect.Semantic proximity Read ↗

The Effect of Heterozygosity for the ACTN3 Null Allele on Human Muscle Performance.Semantic proximity Read ↗

Is evolutionary loss our gain? The role of ACTN3 p.Arg577Ter (R577X) genotype in athletic performance, ageing, and diseaseSemantic proximity Read ↗

History-dependent force, angular velocity and muscular endurance in ACTN3 genotypes.Semantic proximity Read ↗

Association of alpha-actinin-3 genotype with muscle mass and physical function in community-dwelling older adults.Semantic proximity Read ↗

Analysis of the<i>ACTN3</i>heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashionSemantic proximity Read ↗

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