Article
Prion protein gene variation among primates.
Journal of molecular biology - 27 Jan 1995
Schätzl H M, Da Costa M, Taylor L, Cohen F E, Prusiner S B
Abstract excerpt
Prion diseases are manifest as genetic, sporadic or infectious neurodegenerative disorders in humans and animals. The prolonged incubation times that accompany the transmission of prions between species are due, at least in part, to differences in prion protein (PrP) sequence. To examine the species barriers between non-human primates and humans, we sequenced the open reading frames (ORF) of 25 PrP genes from...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Primers
- Genetic Variation
- Humans
- Mice
- Molecular Sequence Data
- Multigene Family
- Phylogeny
- Primates
- Prions