Article
Evaluating human cancer cell metastasis in zebrafish.
BMC cancer - 4 Oct 2013
Teng Yong, Xie Xiayang, Walker Steven, White David T, Mumm Jeff S, Cowell John K
Abstract excerpt
BACKGROUND: In vivo metastasis assays have traditionally been performed in mice, but the process is inefficient and costly. However, since zebrafish do not develop an adaptive immune system until 14 days post-fertilization, human cancer cells can survive and metastasize when transplanted into zebrafish larvae. Despite isolated reports, there has been no systematic evaluation of the robustness of this system to...
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