Article
A Murine Model for Metastatic Conjunctival Melanoma.
Investigative ophthalmology & visual science - 1 Apr 2015
de Waard Nadine E, Cao Jinfeng, McGuire Sean P, Kolovou Paraskevi E, Jordanova Ekaterina S, Ksander Bruce R, Jager Martine J
Abstract excerpt
PURPOSE: Conjunctival melanoma (CM) is an ocular malignancy with a high rate of local recurrences after treatment, and can give rise to deadly metastases. The establishment of a murine model will further our understanding of this disease and allow in vivo testing of new therapies. We therefore analyzed the ability of three CM cell lines to grow orthotopically and spread to distant sites. Furthermore, we...
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