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Article

Obstructing Shedding of the Immunostimulatory MHC Class I Chain–Related Gene B Prevents Tumor Formation

15 Jan 2009

Abstract excerpt

PURPOSE: Clinical observations have suggested that shedding of the MHC class I chain-related molecule (MIC) may be one of the mechanisms by which tumors evade host immunosurveillance and progress. However, this hypothesis has never been proven. In this study, we tested this hypothesis using a prostate tumor model and investigated the effect of shedding of MIC on tumor development. EXPERIMENTAL DESIGN: We...

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Identifiers

PMID: 19147769
DOI: 10.1158/1078-0432.ccr-08-1305

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Obstructing Shedding of the Immunostimulatory MHC Class I Chain–Related Gene B Prevents Tumor FormationPMID 19147769Read ↗

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