Article
Mitochondrial mutations contribute to HIF1alpha accumulation via increased reactive oxygen species and up-regulated pyruvate dehydrogenease kinase 2 in head and neck squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2009
Sun Wenyue, Zhou Shaoyu, Chang Steven S, McFate Thomas, Verma Ajay, Califano Joseph A
Abstract excerpt
PURPOSE: Mitochondrial mutations have been identified in head and neck squamous cell carcinoma (HNSCC), but the pathways by which phenotypic effects of these mutations are exerted remain unclear. Previously, we found that mitochondrial ND2 mutations in primary HNSCC increased reactive oxygen spec...
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