Article

TP53 Mediated Transcriptional Regulation of PHKG2 Promotes Ferroptosis in Head and Neck Squamous Cell Carcinoma by Inhibiting the NRF2/GPX4 Pathway

2024-12-17

Abstract excerpt

<title>Abstract</title> <p>Ferroptosis has emerged as a promising therapeutic target in cancer treatment, yet its regulatory mechanisms in head and neck squamous cell carcinoma (HNSCC) remain poorly understood. This study investigates the role of phosphorylase kinase gamma 2 (PHKG2) in regulating ferroptosis through the TP53/NRF2/GPX4 axis in HNSCC. Using bioinformatics analysis and clinical data evaluation, we i...

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Literature Corpus work: 707337f2-d365-5b18-8293-e7130f912eac
DOI: 10.21203/rs.3.rs-5294943/v1

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